The Frequency and type of Adverse Childhood Events (ACEs) in Patients with known Psychiatric Illness
Abstract
Objective
To determine the frequency and types of adverse childhood experiences (ACEs) among psychiatric outpatients in Karachi, Pakistan, and assess associations with sociodemographic and clinical factors.
Study Design Cross-sectional analysis of 300 psychiatric outpatients from January to May 2025.
Place and Duration of Study
Conducted at the Psychiatry Outpatient Department of Jinnah Postgraduate Medical Centre, Karachi, over five months.
Methods
Participants completed a culturally adapted Adverse Childhood Experiences-International Questionnaire (ACE-IQ), which assesses 13 ACE domains. ICD-11-diagnosed patients(excluding active psychosis) were evaluated. Data analysis using SPSS v23.0 included chi-square tests to examine associations between ACEs, diagnoses, and sociodemographics.
Results
Emotional neglect was the most prevalent ACE (26.57%), followed by physical abuse (17.87%) and emotional abuse (17.87%). Sexual abuse was underreported (6.7%). Household dysfunction included physical neglect (11.11%) and household mental illness (11.11%), while parental separation/divorce was rare (0.48%). Major depressive disorder patients reported higher emotional abuse/neglect, and generalized anxiety disorder patients showed elevated physical abuse, though no ACE reached statistical significance across diagnoses (p > 0.05). Preliterate participants had higher emotional neglect rates (p = 0.019), and parental conflicts marginally correlated with suicidal attempts in schizophrenia (p = 0.019).
Conclusion
ACE patterns in Pakistani psychiatric patients reflect cultural norms, including normalized emotional neglect and familial preservation despite dysfunction. Trauma-informed careaddressing these culturally mediated adversities is critical for improving mental health outcomes.
Keywords
Adverse childhood experiences; Mental disorders; Cross-sectional studies; Pakistan; Trauma-
informed care.
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References
1. McLachlan K, Roters J, Ahmed D, Moulden H, Marshall L. Adverse childhood experiences in forensic psychiatric patients: Prevalence and correlates from two independent Canadian samples. The Journal of Forensic Psychiatry & Psychology [Internet]. 2024 May 3 [cited 2025 May 20];35(3):406–24. Available from:
https://www.tandfonline.com/doi/full/10.1080/14789949.2024.2338905
2. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. REPRINT OF: Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 2019 Jun;56(6):774–86.
3. Arunothong W. Prevalence of Adverse Childhood Events (ACEs) and Its Relationships to Life-Satisfaction Among Patients with Psychiatric Disorders. AJP [Internet]. 2020 [cited 2025 May 20];6(4):421. Available from:
http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=380&doi=10.11648/j.a jp.20200604.15
4. Weiss MJ, Wagner SH. What explains the negative consequences of adverse childhood experiences on adult health? Insights from cognitive and neuroscience research. Am J Prev Med. 1998 May;14(4):356–60.
5. Kibitov AA, Trusova AV, Vyshinsky KV, Mazo GE, Kibitov A. |O. Development and Analysis of Psychometric Properties of a New Russian Version of the Adverse Childhood Experience — International Questionnaire (ACE-IQ). Counseling Psychology and
Psychotherapy [Internet]. 2024 May 7 [cited 2025 May 20];32(1):29–57. Available from: https://psyjournals.ru/en/journals/cpp/archive/2024_n1/Kibitov_Trusova_et_al
6. Arunothong W. 2.18 PREVALENCE OF ADVERSE CHILDHOOD EVENTS (ACES) AND ITS RELATIONSHIP TO LIFE-SATISFACTION AMONG PATIENTS WITH PSYCHIATRIC DISORDERS. Journal of the American Academy of Child & Adolescent Psychiatry [Internet]. 2019 Oct [cited 2025 May 20];58(10):S176–7. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0890856719315679
7. Benarous X, Raffin M, Bodeau N, Dhossche D, Cohen D, Consoli A. Adverse Childhood Experiences Among Inpatient Youths with Severe and Early-Onset Psychiatric Disorders: Prevalence and Clinical Correlates. Child Psychiatry Hum Dev. 2017 Apr;48(2):248–59.
8. Chen W, Yu Z, Wang L, Gross D. Examining Childhood Adversities in Chinese Health Science Students Using the Simplified Chinese Version of the Adverse Childhood Experiences-International Questionnaire (SC-ACE-IQ). Advers Resil Sci [Internet]. 2022 [cited 2025 May 20];3(4):335–46. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580443/
9. Pace CS, Muzi S, Rogier G, Ballestracci E, Mazzola G. The adverse childhood experiences—International questionnaire in clinical and at‐risk samples worldwide: A systematic review (part II). Child Abuse Review [Internet]. 2024 May [cited 2025 May 20];33(3):e2883. Available from: https://onlinelibrary.wiley.com/doi/10.1002/car.2883
10. Van der Feltz-Cornelis CM, de Beurs E. The 10-item Adverse Childhood Experience International Questionnaire (ACE-IQ-10): psychometric properties of the Dutch version in two clinical samples. Eur J Psychotraumatol [Internet]. [cited 2025 May 20];14(2):2216623. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274524/
11. Pace CS, Muzi S, Rogier G, Ballestracci E, Mazzola G. The adverse childhood experiences—International questionnaire in clinical and at‐risk samples worldwide: A systematic review (part II). Child Abuse Review [Internet]. 2024 May [cited 2025 May 20];33(3):e2883. Available from: https://onlinelibrary.wiley.com/doi/10.1002/car.2883
12. Chen W, Yu Z, Wang L, Gross D. Examining Childhood Adversities in Chinese Health Science Students Using the Simplified Chinese Version of the Adverse Childhood Experiences-International Questionnaire (SC-ACE-IQ). Advers Resil Sci [Internet]. 2022 [cited 2025 May 20];3(4):335–46. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580443/
13. Tumlin KI, Crowley A, Turner B, Riley E, Lyons J. Detection of traumatic stress in the presence of traumatic experiences: the role of resilience factors in foster care children five years or younger. Int J Ment Health Syst [Internet]. 2023 Nov 15 [cited 2025 May 20];17:39. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648362/
14. Wilson DH, Nelson KE, Gresh A, Ricker A, Littlepage S, Krienke LK, et al. The Pre implementation Process of Adapting a Culturally Informed Stress Reduction Intervention for Native American Head Start Teachers. Glob Implement Res Appl [Internet]. 2023 [cited
2025 May 20];3(1):16–30. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827016/
15. Koirala R, Iyer Søegaard EG, Kan Z, Ojha SP, Hauff E, Thapa SB. Exploring complex PTSD in patients visiting a psychiatric outpatient clinic in Kathmandu, Nepal. Journal of Psychiatric Research [Internet]. 2021 Nov 1 [cited 2025 May 20];143:23 9. Available from: https://www.sciencedirect.com/science/article/pii/S002239562100529X
16. A comprehensive evaluation of adverse childhood experiences, social–emotional impairments, and neurodevelopmental disorders in cannabis-use disorder: Implications for clinical practice - PMC [Internet]. [cited 2025 May 22]. Available from:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10594251/
17. Mijnster T, Boersma GJ, van Veen MM, Liemburg E, Cath D, Pijnenborg GHM, et al. Sleep disorders in a naturalistic cohort of Dutch psychiatric outpatients: prevalence rates and associations with psychopathology symptom severity and well-being. J Sleep Res. 2024 Apr;33(2):e14009.
18. Gloger S, Martínez P, Behn A, Chacón MV, Cottin M, Diez de Medina D, et al. Population attributable risk of adverse childhood experiences for high suicide risk, psychiatric admissions, and recurrent depression, in depressed outpatients. Eur J Psychotraumatol [Internet]. [cited 2025 May 22];12(1):1874600. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118528/
19. Morán-Sánchez I, Luna A, Pérez-Cárceles MD. Assessment of Capacity to Consent to Research Among Psychiatric Outpatients: Prevalence and Associated Factors. Psychiatr Q. 2016 Mar;87(1):89–105.
20. Honkalampi K, Flink N, Lehto SM, Ruusunen A, Koivumaa-Honkanen H, Valkonen Korhonen M, et al. Adverse childhood experiences and alexithymia in patients with major depressive disorder. Nord J Psychiatry. 2020 Jan;74(1):45–50.
21. Yıldırım YE. Prevalence of Prolonged Grief Disorder and Related Clinical Factors Among Turkish Psychiatric Outpatients During the COVID-19 Pandemic. Omega (Westport) [Internet]. 2023 Jun 30 [cited 2025 May 22];00302228231187296. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315512/
22. Duran Ş, Fıstıkcı N, Keyvan A, Bilici M, Çalışkan M. [ADHD in adult psychiatric outpatients: prevalence and comorbidity]. Turk Psikiyatri Derg. 2014;25(2):84–93.
23. Mendizabal A, Nathan CL, Khankhanian P, Anto M, Clyburn C, Acaba-Berrocal A, et al. Adverse Childhood Experiences in Patients With Neurologic Disease. Neurol Clin Pract. 2022 Feb;12(1):60–7.
24. Byansi W, Galvin M, Chiwaye L, Luvuno Z, Kim AW, Sundararajan R, et al. Adverse childhood experiences, traumatic events, and mental health among adults at two outpatient psychiatric facilities in Johannesburg, South Africa: a cross-sectional analysis. BMC
Psychiatry [Internet]. 2023 Aug 10 [cited 2025 May 22];23:581. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413614/
25. Elrefaay SMM, Elyzal AS. Adverse Childhood Experiences and Depression: The Mediating Role of Resilience and Emotional Regulation. J Psychosoc Nurs Ment Health Serv. 2024 Jan;62(1):45–54.
26. Haapalahti E, Hakko H, Leppänen V, Räsänen S. One-year prevalence and psychiatric comorbidity of borderline personality disorder in a medical certificate population: a registry study of psychiatric outpatients in community mental health care in the city of Oulu. Nord J Psychiatry. 2023 Nov;77(8):811–7.
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