FREQUENCY OF FACTORS RELATED TO NON ADHERENCE IN PATIENTS WITH SCHIZOPHRENIA PRESENTING TO PSYCHIATRY DEPARTMENT AT CIVIL HOSPITAL KARACHI.

Publishing as open access

  • Anaam Bugti SMMBIT-Karachi https://orcid.org/0000-0002-0443-4610
  • Dr Zainab Sher Aga Khan University Hospital
  • Dr Quratulain Yousaf MATRC ANF, Mangopir
  • Dr Anand Parwani Senior Registrar Department of Psychiatry, Ruth K M Pfau Civil Hospital, Karachi
DOI: https://doi.org/10.63050/jpps.22.02.993
Keywords: Non-adherence, Schizophrenia, Antipsychotic medication, Factors, Pakistan.

Abstract

Objective: To determine the factors associated with non-adherence to antipsychotic medication among adult patients with schizophrenia.
Study design: Cross-sectional study

Place and duration of study: The study was conducted at the Department of Psychiatry, Dr. Ruth K.M. Pfau Civil Hospital, Karachi in a period of six months.

Methods: A total of 155 patients were recruited through consecutive sampling. Data on socio-demographic characteristics, clinical history and factors influencing non-adherence were collected using structured interviews.
Results: The mean age of participants was 40.67 ± 11.44 years, with 63.2% being male. Non-adherence to medication was observed in 77.4% of patients, with significant contributing factors including adverse drug effects (61.5%), stigma (42.3%) and financial barriers (46.2%).
Conclusion: Non-adherence to antipsychotic medications is alarmingly high among patients with schizophrenia in Pakistan, necessitating targeted interventions addressing economic, social and clinical challenges to improve adherence rates.
Keywords: Non-adherence, Schizophrenia, Antipsychotic medication, Factors, Pakistan.

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References

1. World Health Organization. Schizophrenia: Key facts. Geneva: WHO; 2019.
2. Insel TR. Rethinking schizophrenia. Nature. 2010;468(7321):187-193.
3. Higashi K, et al. Medication adherence in schizophrenia: factors influencing adherence and consequences of non-adherence. Patient Prefer Adherence. 2013;7:329-342.
4. Kane JM, et al. Comprehensive care in schizophrenia: addressing the challenge of treatment adherence. Clin Ther. 2013;35(2):118-122.
5. Velligan DI, et al. Strategies for addressing adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry. 2010;71(9):1115-1124.
6. Javed A, et al. Mental health services and access in low-income and middle-income countries. Lancet Psychiatry. 2017;4(11):860-870.
7. Gater R, et al. Provision and accessibility of mental health services in low- and middle-income countries. World Psychiatry. 2015;14(2):123-131.
8. Ahmed S, et al. Financial burden and barriers to treatment in schizophrenia. Pak J Med Sci. 2020;36(2):205-210.
9. Lambert M, et al. Impact of side effects on antipsychotic adherence. CNS Drugs. 2004;18(8):541-558.
10. Corrigan PW, et al. Reducing stigma by supporting recovery in people with serious mental illness: a review. Psychiatr Serv. 2012;63(10):963-973.
11. Thornicroft G, et al. Reducing stigma and discrimination: candidate interventions. Int J Ment Health Syst. 2016;10:30.
12. Morisky DE, et al. The validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67-74.
13. Mubeen Z, Fatmi Z, Hameed W, Asim M. Barriers and facilitators to accessing adolescents’ mental health services in Karachi: users and providers perspectives. BMC Health Services Research. 2024 Feb 1;24(1):157.
14. Anastasia EA, Guzman LE, Bridges AJ. Barriers to integrated primary care and specialty mental health services: Perspectives from Latinx and non-Latinx White primary care patients. Educational Publishing Foundation; 2023.
15. World Health Organization. Policy options on mental health: a who-gulbenkian mental health platform collaboration.
Journal of Pakistan Psychiatric Society Volume 22 Issue 02 (April- June 2025)
Published
2025-06-28
How to Cite
1.
Bugti A, Sher DZ, Yousaf DQ, Parwani DA. FREQUENCY OF FACTORS RELATED TO NON ADHERENCE IN PATIENTS WITH SCHIZOPHRENIA PRESENTING TO PSYCHIATRY DEPARTMENT AT CIVIL HOSPITAL KARACHI. J Pak Psychiatr Soc [Internet]. 2025Jun.28 [cited 2025Jul.1];22(02). Available from: https://www.jpps.pk/index.php/journal/article/view/993
Issue
Vol 22 No 02 (2025): Journal of Pakistan Psychiatric Society
Section
Original Article

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